Renin-angiotensin system at the heart of COVID-19 pandemic
Identifieur interne : 000311 ( 2020/Analysis ); précédent : 000310; suivant : 000312Renin-angiotensin system at the heart of COVID-19 pandemic
Auteurs : Marco Alifano [France] ; Pietro Alifano [Italie] ; Patricia Forgez [France] ; Antonio Iannelli [France]Source :
- Biochimie [ 0300-9084 ] ; 2020.
Abstract
Significant aspects of COVID-19 pandemic remain obscure. Angiotensin converting enzyme 2 (ACE2), a component of the renin-angiotensin system, whose expression dominates on lung alveolar epithelial cells, is the human cell receptor of SARS-CoV-2, the causative agent of COVID-19. We strongly encourage the concept that thorough considerations of receptor-ligand interactions should be kept at the heart of scientific debate on infection. In this idea, the whole renin-angiotensin system has to be evaluated. We hypothesize that factors related to ethnicity, environment, behaviors, associated illness, and medications involving this complex system are probably responsible for situations regarded as anomalous from both an epidemiological and a clinical point of view, but, taken together, such factors may explain most of the aspects of current outbreak. We decided to use the analogy of a play and speculate about the possible impact in this tragedy of 1) air pollution via the interference of nitrogen dioxide on ACE2 expression; 2) the dual role of nicotine; 3) the hypothetical involvement of ACE2 polymorphisms, the relationships of which with ethnic factors and susceptibility to cardiovascular disease seems intriguing; 4) the impact on the severity of infection of hypertension and related medications acting on the renin/angiotensin system, and, finally, 5) the possible helpful role of chloroquine, thanks to its capacity of modifying ACE2 affinity to the viral spike protein by altering glycosylation. This hypothesis paper is an urgent call for the development of research programs that aim at questioning whether the putative protagonists of this tragedy are real-life actors in COVID-19.
Url:
DOI: 10.1016/j.biochi.2020.04.008
PubMed: NONE
PubMed Central: 7161528
Affiliations:
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PMC:7161528Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Significant aspects of COVID-19 pandemic remain obscure. Angiotensin converting enzyme 2 (ACE2), a component of the renin-angiotensin system, whose expression dominates on lung alveolar epithelial cells, is the human cell receptor of SARS-CoV-2, the causative agent of COVID-19. We strongly encourage the concept that thorough considerations of receptor-ligand interactions should be kept at the heart of scientific debate on infection. In this idea, the whole renin-angiotensin system has to be evaluated. We hypothesize that factors related to ethnicity, environment, behaviors, associated illness, and medications involving this complex system are probably responsible for situations regarded as anomalous from both an epidemiological and a clinical point of view, but, taken together, such factors may explain most of the aspects of current outbreak. We decided to use the analogy of a play and speculate about the possible impact in this tragedy of 1) air pollution via the interference of nitrogen dioxide on ACE2 expression; 2) the dual role of nicotine; 3) the hypothetical involvement of ACE2 polymorphisms, the relationships of which with ethnic factors and susceptibility to cardiovascular disease seems intriguing; 4) the impact on the severity of infection of hypertension and related medications acting on the renin/angiotensin system, and, finally, 5) the possible helpful role of chloroquine, thanks to its capacity of modifying ACE2 affinity to the viral spike protein by altering glycosylation. This hypothesis paper is an urgent call for the development of research programs that aim at questioning whether the putative protagonists of this tragedy are real-life actors in COVID-19.</p>
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</author>
<author><name sortKey="Karakiulakis, G" uniqKey="Karakiulakis G">G. Karakiulakis</name>
</author>
<author><name sortKey="Roth, M" uniqKey="Roth M">M. Roth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan, J F W" uniqKey="Chan J">J.F.W. Chan</name>
</author>
<author><name sortKey="Kok, K H" uniqKey="Kok K">K.H. Kok</name>
</author>
<author><name sortKey="Zhu, Z" uniqKey="Zhu Z">Z. Zhu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hoffmann, M" uniqKey="Hoffmann M">M. Hoffmann</name>
</author>
<author><name sortKey="Kleine Weber, H" uniqKey="Kleine Weber H">H. Kleine-Weber</name>
</author>
<author><name sortKey="Schroeder, S" uniqKey="Schroeder S">S. Schroeder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tipnis, S R" uniqKey="Tipnis S">S.R. Tipnis</name>
</author>
<author><name sortKey="Hooper, N M" uniqKey="Hooper N">N.M. Hooper</name>
</author>
<author><name sortKey="Hyde, R" uniqKey="Hyde R">R. Hyde</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zheng, Y" uniqKey="Zheng Y">Y. Zheng</name>
</author>
<author><name sortKey="Ma, Y" uniqKey="Ma Y">Y. Ma</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hamming, I" uniqKey="Hamming I">I. Hamming</name>
</author>
<author><name sortKey="Timens, W" uniqKey="Timens W">W. Timens</name>
</author>
<author><name sortKey="Bulthuis, M L" uniqKey="Bulthuis M">M.L. Bulthuis</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q. Zhang</name>
</author>
<author><name sortKey="Cong, M" uniqKey="Cong M">M. Cong</name>
</author>
<author><name sortKey="Wang, N" uniqKey="Wang N">N. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lu, N" uniqKey="Lu N">N. Lu</name>
</author>
<author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pinheiro, D S" uniqKey="Pinheiro D">D.S. Pinheiro</name>
</author>
<author><name sortKey="Santos, R S" uniqKey="Santos R">R.S. Santos</name>
</author>
<author><name sortKey="Jardim, P C B V" uniqKey="Jardim P">P.C.B.V. Jardim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, J" uniqKey="Huang J">J. Huang</name>
</author>
<author><name sortKey="Chen, S" uniqKey="Chen S">S. Chen</name>
</author>
<author><name sortKey="Lu, X" uniqKey="Lu X">X. Lu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Patel, V B" uniqKey="Patel V">V.B. Patel</name>
</author>
<author><name sortKey="Zhong, J C" uniqKey="Zhong J">J.C. Zhong</name>
</author>
<author><name sortKey="Grant, M B" uniqKey="Grant M">M.B. Grant</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meulenbelt, J" uniqKey="Meulenbelt J">J. Meulenbelt</name>
</author>
<author><name sortKey="Van Bree, L" uniqKey="Van Bree L">L. van Bree</name>
</author>
<author><name sortKey="Dormans, J A" uniqKey="Dormans J">J.A. Dormans</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Patel, J M" uniqKey="Patel J">J.M. Patel</name>
</author>
<author><name sortKey="Sekharam, K M" uniqKey="Sekharam K">K.M. Sekharam</name>
</author>
<author><name sortKey="Block, E R" uniqKey="Block E">E.R. Block</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kuan, T C" uniqKey="Kuan T">T.C. Kuan</name>
</author>
<author><name sortKey="Yang, T H" uniqKey="Yang T">T.H. Yang</name>
</author>
<author><name sortKey="Wen, C H" uniqKey="Wen C">C.H. Wen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, B Y" uniqKey="Yang B">B.Y. Yang</name>
</author>
<author><name sortKey="Guo, Y" uniqKey="Guo Y">Y. Guo</name>
</author>
<author><name sortKey="Markevych, I" uniqKey="Markevych I">I. Markevych</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cui, Y" uniqKey="Cui Y">Y. Cui</name>
</author>
<author><name sortKey="Zhang, Z F" uniqKey="Zhang Z">Z.F. Zhang</name>
</author>
<author><name sortKey="Froines, J" uniqKey="Froines J">J. Froines</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="European Space Agency" uniqKey="European Space Agency">European Space Agency</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oakes, J M" uniqKey="Oakes J">J.M. Oakes</name>
</author>
<author><name sortKey="Fuchs, R M" uniqKey="Fuchs R">R.M. Fuchs</name>
</author>
<author><name sortKey="Gardner, J D" uniqKey="Gardner J">J.D. Gardner</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Cole Jeffrey, C T" uniqKey="Cole Jeffrey C">C.T. Cole-Jeffrey</name>
</author>
<author><name sortKey="Liu, M" uniqKey="Liu M">M. Liu</name>
</author>
<author><name sortKey="Katovich, M J" uniqKey="Katovich M">M.J. Katovich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gheblawi, M" uniqKey="Gheblawi M">M. Gheblawi</name>
</author>
<author><name sortKey="Wang, K" uniqKey="Wang K">K. Wang</name>
</author>
<author><name sortKey="Viveiros, A" uniqKey="Viveiros A">A. Viveiros</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mills, K T" uniqKey="Mills K">K.T. Mills</name>
</author>
<author><name sortKey="Bundy, J D" uniqKey="Bundy J">J.D. Bundy</name>
</author>
<author><name sortKey="Kelly, T N" uniqKey="Kelly T">T.N. Kelly</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ferrario, C M" uniqKey="Ferrario C">C.M. Ferrario</name>
</author>
<author><name sortKey="Jessup, J" uniqKey="Jessup J">J. Jessup</name>
</author>
<author><name sortKey="Chappell, M C" uniqKey="Chappell M">M.C. Chappell</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Gao, J" uniqKey="Gao J">J. Gao</name>
</author>
<author><name sortKey="Tian, Z" uniqKey="Tian Z">Z. Tian</name>
</author>
<author><name sortKey="Breakthrough, Yang X" uniqKey="Breakthrough Y">Yang X. Breakthrough</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vincent, M J" uniqKey="Vincent M">M.J. Vincent</name>
</author>
<author><name sortKey="Bergeron, E" uniqKey="Bergeron E">E. Bergeron</name>
</author>
<author><name sortKey="Benjannet, S" uniqKey="Benjannet S">S. Benjannet</name>
</author>
</analytic>
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